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Interstitial deletion of chromosome 15 is responsible for approximately 70-75% of cases of PWS. [Robinson 1991, Smith 2003]

The deletion which includes around 4 Mb of DNA extends from D15S9 through to D15S12. The exact mechanism of the deletion is not fully understood although research has located different breakage sites along the chromosome. One study confirmed the presence of two proximal breakage sites on the chromosome, one lying between D15S41/S542 and D15S543 and the other being proximal to D15S41/S542. [Christian 1995]

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Sally Price 2007  Leeds